Taglich Brothers Initiates Coverage on Opexa Therapeutics, Inc.
NEW YORK, September 1, 2015 - Taglich Brothers, Inc. announces it has initiated coverage of Opexa Therapeutics, Inc.
Opexa Therapeutics, Inc. (NasdaqCM: OPXA), headquartered in The Woodlands, Texas, aims to commercialize its personalized T-cell immunotherapy platform for autoimmune diseases, potentially developing multiple drug candidates tailored specifically for individual patients. The company’s lead product candidate is Tcelna, now under study in a phase IIb trial as a treatment for secondary progressive multiple sclerosis (SPMS). That trial should be completed by mid-2016. If it proves sufficient Tcelna efficacy, the company will pursue a phase III trial and commercialization in the US and Europe through licensee Merck Serono.
OPXA is also developing OPX-212, a treatment for neuromyelitis optica, an autoimmune disorder in which immune system cells and antibodies mistakenly attack and destroy myelin cells in the optic nerves and the spinal cord. The company aims to complete preclinical work this year, potentially filing an Investigational New Study (IND) application by the end of 2015.
Tcelna is a T-cell-based personalized immunotherapy that is adapted to an individual patient’s immune response to myelin, the fatty protective substance that covers the nerves in the brain and spinal cord. The immune system’s myelin reactive T-cells’ (MRTCs) assault on myelin degrades this protective covering and exposes the nerves to damage that impairs their ability to properly transmit signals to the rest of the body, leading to a range of disabilities. Tcelna consists of modified T-cell clones developed from T-cells drawn from a patient’s own blood. Administered by subcutaneous injection, Tcelna triggers an immune system response directed at MRTCs, blocking or moderating their attacks on myelin.
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